Title

NMR of Organomagnesium Compounds

Comments

Copyright © 2008 John Wiley & Sons, Ltd. Metadata only available from this repository. This article was published in the Chemistry of Organomagnesium Compounds by John Wiley and Sons in 2007. The published article is available online at http://onlinelibrary.wiley.com/doi/10.1002/9780470751879.ch3/summary

Abstract

Since their discovery, the exact solution composition of Grignard compounds has been

the subject of considerable debate, and given the power of NMR in elucidating chemical

structure it is unsurprising that it was applied to the study of Grignard and other organomagnesium compounds from its earliest days. However, the complex nature of the solution behaviour of such compounds and the low magnetic field strengths then available often frustrated proper analysis of the data, and the first reported NMR studies were generally inconclusive. Worse, the interpretation of early NMR spectra was often based on preconceived (and as it is now realized incorrect) notions as to the nature of the compounds in solution, so caution must be exercised when considering much of the pre-1970’s data.

Although the advent of higher field NMR instruments and our increasing understanding

of the solution behaviour of organomagnesium reagents have greatly improved the veracity

of NMR studies, detailed NMR reports on such compounds remain relatively sparse. The bulk of the literature that has been published was done so prior to the 1980’s. The reasons

for the paucity of reported NMR studies are probably three-fold: (i) organomagnesium

reagents are generally highly sensitive, making the isolation of sufficiently pure samples

problematic; (ii) different preparations can apparently give quite different NMR spectra;

(iii) the exact solution behaviour depends on a number of factors, making it difficult to

draw any general conclusions.

This paper reviews the current state of the literature on the NMR of Grignard and other organomagnesium compounds.

Disciplines

Chemistry | Inorganic Chemistry | Organic Chemistry | Physical Chemistry

Recommended Citation

Heard, P. J. (2008) NMR of Organomagnesium Compounds, in The Chemistry of Organomagnesium Compounds (eds Z. Rappoport and I. Marek), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470751879.ch3


Link to Full Text

Share

COinS